Prof YUNG, Kin Lam Ken    翁建霖 教授
Chair Professor
Department of Science and Environmental Studies
Associate Vice President (Knowledge Transfer and Sustainability)
Office of the Vice President (Research and Development)
Contact
ORCiD
0000-0002-9588-2573
Phone
(852) 2948 8108
Email
kklyung@eduhk.hk
Address
10 Lo Ping Road, Tai Po, New Territories, Hong Kong
Scopus ID
13605496000
Research Outputs

Journal Publications
Chu, J., Xu, X.F., Xu, Y., Hu, K.F., Chan, H. F., Chen, W.W., Cheung, K.H., Ning, X. H. & Yung, K.K.L. (2026). Bioengineered probiotic-prebiotic hierarchical microspheres with pH-responsive architecture reprogram immunometabolism in obesity-related disorders. Small, 22(26), Article e14910. https://doi.org/10.1002/smll.202514910
Chu, J., Hu, K., Lee, W.F.F., Xu, S.J.L., Sun, Z., Xu, Y., Ning, X. & Yung, K.K.L. (2026). Nanopiezoelectric 3D-bioprinted neural organoid models epileptic neuron–microglia circuit in neurodegeneration. Nano Letters, 26, 4339-4347. https://doi.org/10.1021/acs.nanolett.5c06156
Yi, X., Zhang, S.Q., Gu, X.P., Wu, X.Y., Ma, L., Xu, Y.D., Lv, S., Huang, J.J., Zhi, Y.X., Cao, Y., Cao, X., Li, F.X., Chen, G.B., Liu, S.W., Yung, K.K.L. & Zhou, P.Z. (2026). VRAC coordinates the trade-off between nutrient absorption and antimicrobial defense in enterocytes against inflammation. Nature Communications, 17, Article 3146. https://doi.org/10.1038/s41467-026-69963-3
Peng, J.J., Ou, Y.C., Zhou, M.F., Wang, X.Q., Zhang, X., Long, H., Wu, G.S., Che, M.G., Li, K., Yang, L., Zhang, Z., Yung, K.K.L., Qi, S.T. & Feng, Z.P. (2026). Setmelanotide-mediated MC4R activation improves hypothalamic obesity via CaMKK2/AMPK pathways. Frontiers in Pharmacology, 16, Article 1730786. https://doi.org/10.3389/fphar.2025.1730786
Wang, S.X., Gao, M., Wang, Z., Ding, Y.H., Luo, J.J., Wu, Z.W., Li, Q.X., Lu, X., Yang, Y.J., Yung, K.K.L., Zuo, B., McElroy, M.B. & Li, Z.G. (2025). A revival of climate-projected hydropower potential at the Three Gorges hydropower station driven by migrated global warming hotspots. Cell Reports Sustainability, 2(12), Article 100586. https://doi.org/10.1016/j.crsus.2025.100586
Chen, W.Q., Chen, S.S., Bai, L.R., Zhao, L.F., Zhang, M., Dong, C., Yang, Z., Song, Y.Y., Yung, K.K.L. & Cai, Z.W. (2025). Combined exposure to high-cholesterol diet and PM2.5: Brain injury, behavioral alteration and regulatory mechanism of HIF-1α in female mice. Journal of Biochemical and Molecular Toxicology, 39(11), Article e70568. https://doi.org/10.1002/jbt.70568
Luo, B.Y., Yi, X., Cai, Y.J., Zhang, S.Q., Wang, P., Li, T., Yung, K.K.L & Zhou, P.Z. (2025)。 清心牛黃丸通過改善脂質代謝紊亂緩解小鼠非酒精性脂肪性肝病。 南方醫科大學學報,45(9),1840-1849。 https://doi.org/10.12122/j.issn.1673-4254.2025.09.04

Jiang, X.L., Li, J.K., Zhu, P.L., Zeng, K., Liu, B., Zhang, J., Yung, K.K-L., & Deng, B. (2025). Danshen (Salvia miltiorrhiza) extract suppresses the growth of melanoma cells and induces autophagy by inhibiting the STAT3 pathway. Journal of Ethnopharmacology, 351, Article 120086. https://doi.org/10.1016/j.jep.2025.120086  


Jiang, X.L., Liu, B., Li, J.-K., Lin. Y.F., Zhu, P.L., Zhang, Z., Wang, Y., Deng, B., Zhang, J.Z., & Yung, K.K.L. (2025). Przewaquinone A, as a natural STAT3 inhibitor, suppresses the growth of melanoma cells and induces autophagy. Phytomedicine, 142, Article 156810. https://doi.org/10.1016/j.phrs.2025.107623
Luo, H., Cai, Y., Shi, H., Ma, L., Zhang, S., Yung, K. K. L., & Zhou, P. (2025). Repurposing oxiconazole to inhibit STING trafficking via OSBP and alleviate autoimmune pathology in Trex1−/− mice. International Immunopharmacology, 157, Article 114742. https://doi.org/10.1016/j.intimp.2025.114742 
Sun, Z., Fu, P., Zhang, S., & Yung, K.K.L. (2025). Bioinformatic Identification of Risk Factors from an Immunological Viewpoint in Idiopathic Parkinson's Disease. Journal of Neurorestoratology, 13, Article 100177. https://doi.org/10.1016/j.jnrt.2024.100177
Chen, Y., Zhi, Y., Zhong, H., Ma, L., Gu, X., Cai, Y., Huang, J., Yi, X., Wu, X., Yung, K. K. L., & Zhou, P. (2025). Inhibition of Kv1.3 channel restrains macrophage M2 polarization and ameliorates renal fibrosis via regulating STAT6 phosphorylation. Pharmacological Research, 213, Article 107623. https://doi.org/10.1016/j.phrs.2025.107623  
Wang, C., Lin, K., Zhang, Z., Pan, Y., Miao, Q., Han, X., Zhang, Z., Zhu, P., Yang, J., Peng, Y., Yung, K.K.L., Shi, L., & Zhang, S. (2025). Adolescent Exposure to Micro/nanoplastics Induces Cognitive Impairments in Mice with Neuronal Morphological Damage and Multi-omic Alterations. Environment International, 197, Article 109323. https://doi.org/10.1016/j.envint.2025.109323 
Tam, S. W., Cheung, A. K. L., Qin, P., Zhang, S., Huang, Z., & Yung, K. K. L. (2025). Extracellular silica nanomatrices promote in vitro maturation of anti-tumor dendritic cells via activation of focal adhesion kinase. Advanced Materials, 37(2), Article 2314358. https://doi.org/10.1002/adma.202314358 
Yang, S., Xue, J., Li, Z., Zhang, S., Zhang, Z., Huang, Z., Yung, K.K.L., & Lai, K.W.C. (2024). Deep learning-based ion channel kinetics analysis for automated patch clamp recording. Advanced Science. Advance online publication. https://doi.org/10.1002/advs.202404166  
Li, J.K., Jiang, X.L., Zhang, Z., Chen, W.Q., Peng, J.J., Liu, B., Yung, K. K.L., & Zhu, P.L. (2024). 20(S)-Ginsenoside Rh2 induces apoptosis and autophagy in melanoma cells via suppressing Src/STAT3 signaling. Journal of Ginseng Research, 48(6), 559-569. https://doi.org/10.1016/j.jgr.2024.07.002
Wu, X., Yi, X., Zhao, B., Zhi, Y., Xu, Z., Cao, Y., Cao, X. Pang, J., Yung, K.K.L., Zhang, S., Liu, S. & Zhou, P. (2023). The Volume Regulated Anion Channel VRAC Regulates NLRP3 Inflammasome by Modulating Itaconate Efflux and Mitochondria Function. Pharmacological Research, 198, Article 107016. https://doi.org/10.1016/j.phrs.2023.107016

Fu, P., Li, R., Sze, S.C.W., & Yung, K.K. L. (2024). Associations between fine particulate matter and colorectal cancer: A systematic review and meta-analysis. Reviews on Environmental Health, 39(3), 447-457. https://doi.org/10.1515/reveh-2022-0222  



Projects

Systematic Review of Exosome-Delivered Growth Factors for Rejuvenating Aged Neural Stem Cells
This review research study aims to systematically review existing literature on exosome-delivered growth factors and their effects on aged neural stem cells. The study will focus on analyzing methodologies, outcomes, and gaps in current research to provide a comprehensive understanding of the potential of Exo-EGF/bFGF for NSC rejuvenation. By synthesizing published data, this study will identify optimal strategies for future experimental designs and highlight directions for translational applications.
Project Start Year: 2025, Principal Investigator(s): YUNG, Kin Lam, Ken

 
Neuroscience Research and Application of Smart Calligraphy for Cognitive Development

Project Start Year: 2025, Principal Investigator(s): YUNG, Kin Lam, Ken

 
Roles of Ginsenosides and Other Active Ingredients of Traditional Chinese Medicine in Prevention of Cell Death in the Brain

Project Start Year: 2024, Principal Investigator(s): YUNG, Kin Lam, Ken

 
Study of TWIK2 channel as the Key Therapeutic Target for Parkinson's Disease

Project Start Year: 2024, Principal Investigator(s): YUNG, Kin Lam, Ken

 
Prizes and awards

Special Merit Award
Prof YUNG Kin Lam Ken's "Novel Biomaterials Used for Dendritic Cell Vaccine for Cancer Immunotherapy" won a Gold Medal and Special Merit Award from the Geneva 2025
Date of receipt: 1/4/2025, Conferred by: International Exhibitions of Inventions Geneva 2025
 
Gold Medal
Prof YUNG Kin Lam Ken's "Novel Biomaterials Used for Dendritic Cell Vaccine for Cancer Immunotherapy" won a Gold Medal and Special Merit Award from the Geneva 2025
Date of receipt: 1/4/2025, Conferred by: International Exhibitions of Inventions Geneva 2025