Profile of Prof YUNG, Kin Lam Ken 翁建霖 - The Education University of Hong Kong


Chair Professor	Department of Science and Environmental Studies
Associate Vice President (Knowledge Transfer and Sustainability)	Office of the Vice President (Research and Development)

Contact

ORCiD

0000-0002-9588-2573

Phone

(852) 2948 8108

kklyung@eduhk.hk

Address

10 Lo Ping Road, Tai Po, New Territories, Hong Kong

Website

https://pappl.eduhk.hk/rich/web/person.xhtml?pid=307023&name=YUNG, Kin Lam Ken

Scopus ID

13605496000

Research Outputs


Journal Publications Chu, J., Xu, X.F., Xu, Y., Hu, K.F., Chan, H.F., Chen, W., Cheung, K.H., Ning, X.H. & Yung, K.K.L. (2026). Bioengineered probiotic-prebiotic hierarchical microspheres with pH-responsive architecture reprogram immunometabolism in obesity-related disorders. Small, 22(26), Article e14910. https://doi.org/10.1021/acs.nanolett.5c06156 Che, M., Feng, Z., Xu, W., Ling, X., Zhou, M., Peng, J., Wu, G., Li, K., Peng, J., Yung, K.L.K., Zhang, Z., Wang, H., Cai, Y., Liang, X., Zhang, X., Qi, S., & Ou, Y. (2026). Hypothalamic arcuate microglia in sepsis: AgRP circuit engagement and ARHGAP24-dependent remodeling. Journal of Neuroinflammation, 23, Article 248. https://doi.org/10.1186/s12974-026-03786-3 Chu, J., Hu, K., Lee, W.F.F., Xu, S.J.L., Sun, Z., Xu, Y., Ning, X. & Yung, K.K.L. (2026). Nanopiezoelectric 3D-bioprinted neural organoid models epileptic neuron–microglia circuit in neurodegeneration. Nano Letters, 26, 4339-4347. https://doi.org/10.1021/acs.nanolett.5c06156 Yi, X., Zhang, S.Q., Gu, X.P., Wu, X.Y., Ma, L., Xu, Y.D., Lv, S., Huang, J.J., Zhi, Y.X., Cao, Y., Cao, X., Li, F.X., Chen, G.B., Liu, S.W., Yung, K.K.L. & Zhou, P.Z. (2026). VRAC coordinates the trade-off between nutrient absorption and antimicrobial defense in enterocytes against inflammation. Nature Communications, 17, Article 3146. https://doi.org/10.1038/s41467-026-69963-3 Peng, J., Ou, Y., Zhou, M., Wang, X., Zhang, X., Long, H., Wu, G., Che, M., Li, K., Yang, L., Zhang, Z., Yung, K.K.L., Qi, S., & Feng, Z. (2026). Setmelanotide-mediated MC4R activation improves hypothalamic obesity via CaMKK2/AMPK pathways. Frontiers in Pharmacology, 16, Article 1730786. https://doi.org/10.3389/fphar.2025.1730786 Wang, S., Gao, M., Wang, Z., Ding, Y., Luo, J., Wu, Z., Li, Q., Lu, X., Yang, Y., Yung, K.K.L., Zuo, B., McElroy, M.B., & Li, Z. (2025). A revival of climate-projected hydropower potential at the Three Gorges hydropower station driven by migrated global warming hotspots. Cell Reports Sustainability, 2(12), Article 100586. https://doi.org/10.1016/j.crsus.2025.100586 Chen, W., Chen, S., Bai, L., Zhao, L., Zhang, M., Dong, C., Yang, Z., Song, Y., Yung, K.K.L., Cai, Z., & Li, R. (2025). Combined exposure to high-cholesterol diet and PM2.5: Brain injury, behavioral alteration and regulatory mechanism of HIF-1α in female mice. Journal of Biochemical and Molecular Toxicology, 39(11), Article e70568. https://doi.org/10.1002/jbt.70568 駱碧雲、易欣、蔡怡靜、張世卿、王鵬、李彤、翁建霖和周平正 (2025)。清心牛黃丸通過改善脂質代謝紊亂緩解小鼠非酒精性脂肪性肝病。南方醫科大學學報，45(9)，1840-1849。 https://doi.org/10.12122/j.issn.1673-4254.2025.09.04 Jiang, X.L., Li, J.K., Zhu, P.L., Zeng, K., Liu, B., Zhang, J., Yung, K.K-L., & Deng, B. (2025). Danshen (Salvia miltiorrhiza) extract suppresses the growth of melanoma cells and induces autophagy by inhibiting the STAT3 pathway. Journal of Ethnopharmacology, 351, Article 120086. https://doi.org/10.1016/j.jep.2025.120086 Jiang, X.L., Liu, B., Li, J.-K., Lin. Y.F., Zhu, P.L., Zhang, Z., Wang, Y., Deng, B., Zhang, J.Z., & Yung, K.K.L. (2025). Przewaquinone A, as a natural STAT3 inhibitor, suppresses the growth of melanoma cells and induces autophagy. Phytomedicine, 142, Article 156810. https://doi.org/10.1016/j.phrs.2025.107623 Luo, H., Cai, Y., Shi, H., Ma, L., Zhang, S., Yung, K. K. L., & Zhou, P. (2025). Repurposing oxiconazole to inhibit STING trafficking via OSBP and alleviate autoimmune pathology in Trex1−/− mice. International Immunopharmacology, 157, Article 114742. https://doi.org/10.1016/j.intimp.2025.114742 Sun, Z., Fu, P., Zhang, S., & Yung, K.K.L. (2025). Bioinformatic Identification of Risk Factors from an Immunological Viewpoint in Idiopathic Parkinson's Disease. Journal of Neurorestoratology, 13, Article 100177. https://doi.org/10.1016/j.jnrt.2024.100177 Chen, Y., Zhi, Y., Zhong, H., Ma, L., Gu, X., Cai, Y., Huang, J., Yi, X., Wu, X., Yung, K. K. L., & Zhou, P. (2025). Inhibition of Kv1.3 channel restrains macrophage M2 polarization and ameliorates renal fibrosis via regulating STAT6 phosphorylation. Pharmacological Research, 213, Article 107623. https://doi.org/10.1016/j.phrs.2025.107623 Wang, C., Lin, K., Zhang, Z., Pan, Y., Miao, Q., Han, X., Zhang, Z., Zhu, P., Yang, J., Peng, Y., Yung, K.K.L., Shi, L., & Zhang, S. (2025). Adolescent Exposure to Micro/nanoplastics Induces Cognitive Impairments in Mice with Neuronal Morphological Damage and Multi-omic Alterations. Environment International, 197, Article 109323. https://doi.org/10.1016/j.envint.2025.109323 Tam, S. W., Cheung, A. K. L., Qin, P., Zhang, S., Huang, Z., & Yung, K. K. L. (2025). Extracellular silica nanomatrices promote in vitro maturation of anti-tumor dendritic cells via activation of focal adhesion kinase. Advanced Materials, 37(2), Article 2314358. https://doi.org/10.1002/adma.202314358 Yang, S., Xue, J., Li, Z., Zhang, S., Zhang, Z., Huang, Z., Yung, K.K.L., & Lai, K.W.C. (2024). Deep learning-based ion channel kinetics analysis for automated patch clamp recording. Advanced Science. Advance online publication. https://doi.org/10.1002/advs.202404166 Li, J.K., Jiang, X.L., Zhang, Z., Chen, W.Q., Peng, J.J., Liu, B., Yung, K. K.L., & Zhu, P.L. (2024). 20(S)-Ginsenoside Rh2 induces apoptosis and autophagy in melanoma cells via suppressing Src/STAT3 signaling. Journal of Ginseng Research, 48(6), 559-569. https://doi.org/10.1016/j.jgr.2024.07.002 Wu, X., Yi, X., Zhao, B., Zhi, Y., Xu, Z., Cao, Y., Cao, X. Pang, J., Yung, K.K.L., Zhang, S., Liu, S. & Zhou, P. (2023). The Volume Regulated Anion Channel VRAC Regulates NLRP3 Inflammasome by Modulating Itaconate Efflux and Mitochondria Function. Pharmacological Research, 198, Article 107016. https://doi.org/10.1016/j.phrs.2023.107016 Fu, P., Li, R., Sze, S.C.W., & Yung, K.K. L. (2024). Associations between fine particulate matter and colorectal cancer: A systematic review and meta-analysis. Reviews on Environmental Health, 39(3), 447-457. https://doi.org/10.1515/reveh-2022-0222

Journal Publications
Chu, J., Xu, X.F., Xu, Y., Hu, K.F., Chan, H.F., Chen, W., Cheung, K.H., Ning, X.H. & Yung, K.K.L. (2026). Bioengineered probiotic-prebiotic hierarchical microspheres with pH-responsive architecture reprogram immunometabolism in obesity-related disorders. Small, 22(26), Article e14910. https://doi.org/10.1021/acs.nanolett.5c06156
Che, M., Feng, Z., Xu, W., Ling, X., Zhou, M., Peng, J., Wu, G., Li, K., Peng, J., Yung, K.L.K., Zhang, Z., Wang, H., Cai, Y., Liang, X., Zhang, X., Qi, S., & Ou, Y. (2026). Hypothalamic arcuate microglia in sepsis: AgRP circuit engagement and ARHGAP24-dependent remodeling. Journal of Neuroinflammation, 23, Article 248. https://doi.org/10.1186/s12974-026-03786-3
Chu, J., Hu, K., Lee, W.F.F., Xu, S.J.L., Sun, Z., Xu, Y., Ning, X. & Yung, K.K.L. (2026). Nanopiezoelectric 3D-bioprinted neural organoid models epileptic neuron–microglia circuit in neurodegeneration. Nano Letters, 26, 4339-4347. https://doi.org/10.1021/acs.nanolett.5c06156
Yi, X., Zhang, S.Q., Gu, X.P., Wu, X.Y., Ma, L., Xu, Y.D., Lv, S., Huang, J.J., Zhi, Y.X., Cao, Y., Cao, X., Li, F.X., Chen, G.B., Liu, S.W., Yung, K.K.L. & Zhou, P.Z. (2026). VRAC coordinates the trade-off between nutrient absorption and antimicrobial defense in enterocytes against inflammation. Nature Communications, 17, Article 3146. https://doi.org/10.1038/s41467-026-69963-3
Peng, J., Ou, Y., Zhou, M., Wang, X., Zhang, X., Long, H., Wu, G., Che, M., Li, K., Yang, L., Zhang, Z., Yung, K.K.L., Qi, S., & Feng, Z. (2026). Setmelanotide-mediated MC4R activation improves hypothalamic obesity via CaMKK2/AMPK pathways. Frontiers in Pharmacology, 16, Article 1730786. https://doi.org/10.3389/fphar.2025.1730786
Wang, S., Gao, M., Wang, Z., Ding, Y., Luo, J., Wu, Z., Li, Q., Lu, X., Yang, Y., Yung, K.K.L., Zuo, B., McElroy, M.B., & Li, Z. (2025). A revival of climate-projected hydropower potential at the Three Gorges hydropower station driven by migrated global warming hotspots. Cell Reports Sustainability, 2(12), Article 100586. https://doi.org/10.1016/j.crsus.2025.100586
Chen, W., Chen, S., Bai, L., Zhao, L., Zhang, M., Dong, C., Yang, Z., Song, Y., Yung, K.K.L., Cai, Z., & Li, R. (2025). Combined exposure to high-cholesterol diet and PM2.5: Brain injury, behavioral alteration and regulatory mechanism of HIF-1α in female mice. Journal of Biochemical and Molecular Toxicology, 39(11), Article e70568. https://doi.org/10.1002/jbt.70568
駱碧雲、易欣、蔡怡靜、張世卿、王鵬、李彤、翁建霖和周平正 (2025)。清心牛黃丸通過改善脂質代謝紊亂緩解小鼠非酒精性脂肪性肝病。南方醫科大學學報，45(9)，1840-1849。 https://doi.org/10.12122/j.issn.1673-4254.2025.09.04

Jiang, X.L., Li, J.K., Zhu, P.L., Zeng, K., Liu, B., Zhang, J., Yung, K.K-L., & Deng, B. (2025). Danshen (Salvia miltiorrhiza) extract suppresses the growth of melanoma cells and induces autophagy by inhibiting the STAT3 pathway. Journal of Ethnopharmacology, 351, Article 120086. https://doi.org/10.1016/j.jep.2025.120086

Jiang, X.L., Liu, B., Li, J.-K., Lin. Y.F., Zhu, P.L., Zhang, Z., Wang, Y., Deng, B., Zhang, J.Z., & Yung, K.K.L. (2025). Przewaquinone A, as a natural STAT3 inhibitor, suppresses the growth of melanoma cells and induces autophagy. Phytomedicine, 142, Article 156810. https://doi.org/10.1016/j.phrs.2025.107623
Luo, H., Cai, Y., Shi, H., Ma, L., Zhang, S., Yung, K. K. L., & Zhou, P. (2025). Repurposing oxiconazole to inhibit STING trafficking via OSBP and alleviate autoimmune pathology in Trex1−/− mice. International Immunopharmacology, 157, Article 114742. https://doi.org/10.1016/j.intimp.2025.114742
Sun, Z., Fu, P., Zhang, S., & Yung, K.K.L. (2025). Bioinformatic Identification of Risk Factors from an Immunological Viewpoint in Idiopathic Parkinson's Disease. Journal of Neurorestoratology, 13, Article 100177. https://doi.org/10.1016/j.jnrt.2024.100177
Chen, Y., Zhi, Y., Zhong, H., Ma, L., Gu, X., Cai, Y., Huang, J., Yi, X., Wu, X., Yung, K. K. L., & Zhou, P. (2025). Inhibition of Kv1.3 channel restrains macrophage M2 polarization and ameliorates renal fibrosis via regulating STAT6 phosphorylation. Pharmacological Research, 213, Article 107623. https://doi.org/10.1016/j.phrs.2025.107623
Wang, C., Lin, K., Zhang, Z., Pan, Y., Miao, Q., Han, X., Zhang, Z., Zhu, P., Yang, J., Peng, Y., Yung, K.K.L., Shi, L., & Zhang, S. (2025). Adolescent Exposure to Micro/nanoplastics Induces Cognitive Impairments in Mice with Neuronal Morphological Damage and Multi-omic Alterations. Environment International, 197, Article 109323. https://doi.org/10.1016/j.envint.2025.109323
Tam, S. W., Cheung, A. K. L., Qin, P., Zhang, S., Huang, Z., & Yung, K. K. L. (2025). Extracellular silica nanomatrices promote in vitro maturation of anti-tumor dendritic cells via activation of focal adhesion kinase. Advanced Materials, 37(2), Article 2314358. https://doi.org/10.1002/adma.202314358
Yang, S., Xue, J., Li, Z., Zhang, S., Zhang, Z., Huang, Z., Yung, K.K.L., & Lai, K.W.C. (2024). Deep learning-based ion channel kinetics analysis for automated patch clamp recording. Advanced Science. Advance online publication. https://doi.org/10.1002/advs.202404166
Li, J.K., Jiang, X.L., Zhang, Z., Chen, W.Q., Peng, J.J., Liu, B., Yung, K. K.L., & Zhu, P.L. (2024). 20(S)-Ginsenoside Rh2 induces apoptosis and autophagy in melanoma cells via suppressing Src/STAT3 signaling. Journal of Ginseng Research, 48(6), 559-569. https://doi.org/10.1016/j.jgr.2024.07.002
Wu, X., Yi, X., Zhao, B., Zhi, Y., Xu, Z., Cao, Y., Cao, X. Pang, J., Yung, K.K.L., Zhang, S., Liu, S. & Zhou, P. (2023). The Volume Regulated Anion Channel VRAC Regulates NLRP3 Inflammasome by Modulating Itaconate Efflux and Mitochondria Function. Pharmacological Research, 198, Article 107016. https://doi.org/10.1016/j.phrs.2023.107016

Fu, P., Li, R., Sze, S.C.W., & Yung, K.K. L. (2024). Associations between fine particulate matter and colorectal cancer: A systematic review and meta-analysis. Reviews on Environmental Health, 39(3), 447-457. https://doi.org/10.1515/reveh-2022-0222

Projects


Systematic Review of Exosome-Delivered Growth Factors for Rejuvenating Aged Neural Stem Cells This review research study aims to systematically review existing literature on exosome-delivered growth factors and their effects on aged neural stem cells. The study will focus on analyzing methodologies, outcomes, and gaps in current research to provide a comprehensive understanding of the potential of Exo-EGF/bFGF for NSC rejuvenation. By synthesizing published data, this study will identify optimal strategies for future experimental designs and highlight directions for translational applications. Project Start Year: 2025, Principal Investigator(s): YUNG, Kin Lam, Ken
Systematic Review of Exosome-Delivered Growth Factors for Rejuvenating Aged Neural Stem Cells This review research study aims to systematically review existing literature on exosome-delivered growth factors and their effects on aged neural stem cells. The study will focus on analyzing methodologies, outcomes, and gaps in current research to provide a comprehensive understanding of the potential of Exo-EGF/bFGF for NSC rejuvenation. By synthesizing published data, this study will identify optimal strategies for future experimental designs and highlight directions for translational applications. Project Start Year: 2025, Principal Investigator(s): YUNG, Kin Lam, Ken
Neuroscience Research and Application of Smart Calligraphy for Cognitive Development Project Start Year: 2025, Principal Investigator(s): YUNG, Kin Lam, Ken
Neuroscience Research and Application of Smart Calligraphy for Cognitive Development Project Start Year: 2025, Principal Investigator(s): YUNG, Kin Lam, Ken
Roles of Ginsenosides and Other Active Ingredients of Traditional Chinese Medicine in Prevention of Cell Death in the Brain Project Start Year: 2024, Principal Investigator(s): YUNG, Kin Lam, Ken
Study of TWIK2 channel as the Key Therapeutic Target for Parkinson's Disease Project Start Year: 2024, Principal Investigator(s): YUNG, Kin Lam, Ken

Prizes and awards


Gold Medal Prof Ken Yung's "Novel Biomaterials Used for Dendritic Cell Vaccine for Cancer Immunotherapy" won the Prize of the International Exhibition of Inventions Geneva and a Gold Medal at the 5th Asia Exhibition of Innovations and Inventions. Date of receipt: 5/12/2025, Conferred by: 5th Asia Exhibition of Innovations and Inventions
Prize of the International Exhibition of Inventions Geneva Prof Ken Yung's "Novel Biomaterials Used for Dendritic Cell Vaccine for Cancer Immunotherapy" won the Prize of the International Exhibition of Inventions Geneva and a Gold Medal at the 5th Asia Exhibition of Innovations and Inventions. Date of receipt: 5/12/2025, Conferred by: 5th Asia Exhibition of Innovations and Inventions
Top 20 Best Invention Awards Prof Ken Yung's "Novel Biomaterials Used for Dendritic Cell Vaccine for Cancer Immunotherapy" won the Top 20 Best Invention Award, a Gold Medal, and the Canadian Special Award (The Inventors Circle) at the International Invention Innovation Competition in Canada 2025. Date of receipt: 30/8/2025, Conferred by: International Invention Innovation Competition in Canada (iCan) 2025
Canadian Special Award (International Invention Innovation Competition in Canada) Prof Ken Yung's "Novel Biomaterials Used for Dendritic Cell Vaccine for Cancer Immunotherapy" won the Top 20 Best Invention Award, a Gold Medal, and the Canadian Special Award (The Inventors Circle) at the International Invention Innovation Competition in Canada 2025. Date of receipt: 30/8/2025, Conferred by: International Invention Innovation Competition in Canada (iCan) 2025
Gold Medal Prof Ken Yung's "Novel Biomaterials Used for Dendritic Cell Vaccine for Cancer Immunotherapy" won the Top 20 Best Invention Award, a Gold Medal, and the Canadian Special Award (The Inventors Circle) at the International Invention Innovation Competition in Canada 2025. Date of receipt: 30/8/2025, Conferred by: International Invention Innovation Competition in Canada (iCan) 2025
The WIPO National Award for Inventors The project, titled ‘Novel Biomaterials Used for Dendritic Cell Vaccine for Cancer Immunotherapy’, was led by Professor Ken Yung Kin-lam. This project received the WIPO National Award for Inventors. This project also received Gold Medal. Date of receipt: 10/8/2025, Conferred by: The Silicon Valley International Invention Festival (SVIIF)
Gold Medal Prof Ken Yung's "Novel Biomaterials Used for Dendritic Cell Vaccine for Cancer Immunotherapy" won the WIPO National Award for Inventors and a Gold Medal at the Silicon Valley International Invention Festival (SVIIF) 2025. Date of receipt: 10/8/2025, Conferred by: Silicon Valley International Invention Festival (SVIIF) 2025
Gold Medal Prof Ken Yung's "Novel Biomaterials Used for Dendritic Cell Vaccine for Cancer Immunotherapy" won a Gold Medal at BRICS Invention 2025. Date of receipt: 29/7/2025, Conferred by: BRICS Invention 2025
Gold Medal Prof YUNG Kin Lam Ken's "Novel Biomaterials Used for Dendritic Cell Vaccine for Cancer Immunotherapy" won a Gold Medal and Special Merit Award from the Geneva 2025 Date of receipt: 1/4/2025, Conferred by: International Exhibitions of Inventions Geneva 2025
Special Merit Award Prof YUNG Kin Lam Ken's "Novel Biomaterials Used for Dendritic Cell Vaccine for Cancer Immunotherapy" won a Gold Medal and Special Merit Award from the Geneva 2025 Date of receipt: 1/4/2025, Conferred by: International Exhibitions of Inventions Geneva 2025