Profile of Dr LAU, Kwok Wai 劉國威 - The Education University of Hong Kong


Assistant Professor	Department of Special Education and Counselling

Contact

ORCiD

0000-0003-1493-5002

Phone

(852) 2948 8567

Fax

(852) 2948 7794

waylau@eduhk.hk

Address

10 Lo Ping Road, Tai Po, New Territories, Hong Kong

Website

https://pappl.eduhk.hk/rich/web/person.xhtml?pid=196421&name=LAU, Kwok Wai

Scopus ID

35292424400

ResearcherID

K-9444-2015

Research Interest

Stress and resilience
Psychobiology
Pathophysiology of Autism Spectrum Disorder
Molecular and multidisciplinary neuroscience

Research Interest

Stress and resilience
Psychobiology
Pathophysiology of Autism Spectrum Disorder
Molecular and multidisciplinary neuroscience

Selected Output


Scholarly Books, Monographs and Chapters Leung, M.K., & Lau, W.K.W. (2020). Resting-state abnormalities of posterior cingulate in autism spectrum disorder. ., In Progress in molecular biology and translational science (.-.). Cambridge, MA: Academic Press, an imprint of Elsevier. (in press) Leung, J. W. H., Lau, W. K. W., Lau, B. W. M., & Yee, B. K. (2019). A commentary on the therapeutic potential of melatonin and its analogues in CNS conditions. In P. A. Garguilo, H. L. Mesones Arroyo (Eds.), Psychiatry and Neuroscience Update (177-186). Cham: Springer International Publishing
Journal Publications Lau, W. K. W. (2022). The role of resilience in depression and anxiety symptoms: A three-wave cross-lagged study. Stress and Health Doi:10.1002/smi.3136. Zhu, Z., Wang, Y., Lau, W. K. W., Wei, X., Liu, Y., Huang, R., & Zhang, R. (2022). Hyperconnectivity between the posterior cingulate and middle frontal and temporal gyrus in depression: Based on functional connectivity meta-analyses. Brain Imaging and Behavior Doi:10.1007/s11682-022-00628-7. Lau, W. K., Ngan, L. H., Chan, R. C., Wu, W. K., Lau, B. W. (2021). Impact of COVID-19 on pornography use: evidence from big data analyses. PLoS One, ., .-. Tai, A. P., Lau, W. K. (2021). Revisit the Effectiveness of Educational Kinesiology on Stress and Anxiety Amelioration in Kindergarteners with Special Needs using Biological Measures. Frontiers in Psychiatry, 12, .-. Wang, C., Wang, Y., Lau, W. K. W., Wei, X., Feng, X., Zhang, C., . . . Zhang, R. (2021). Anomalous static and dynamic functional connectivity of amygdala subregions in individuals with high trait anxiety. Depression and Anxiety, 38(8), 860-873 Zhao, G., Lau, W. K., Wang, C., Yan, H., Zhang, C., Lin, K., ... & Zhang, R. (2021). A Comparative Multimodal Meta-analysis of Anisotropy and Volume Abnormalities in White Matter in People Suffering From Bipolar Disorder or Schizophrenia. Schizophrenia Bulletin, ., .-. Lau, W. K. W., Tai, A. P. L., Chan, J. N. M., Lau, B. W. M., & Geng, X. (2021). Integrative psycho-biophysiological markers in predicting psychological resilience. Psychoneuroendocrinology, 129, .-. Lau, W. K. W., Tai, A. P. L., & Lau, C. S. Y. (2021). An integrated training approach for ameliorating repetitive behavior in children with autism spectrum disorder: A pilot study.. Hong Kong Journal of Special Education., 22, 1-16 Peng, X., Lau, W. K. W., Wang, C., Ning, L., & Zhang, R. (2020). Impaired left amygdala resting state functional connectivity in subthreshold depression individuals. Scientific Reports, 10(1), .-. Lau, W.K.W., Leung, M.K. & Zhang, R (2020). Hypofunctional connectivity between the posterior cingulate cortex and ventromedial prefrontal cortex in autism: evidence from coordinate-based imaging meta-analysis. Progress in neuropsychopharmacology and  biological psychiatry, in press, .-. Tam, S. W., Feng, R., Lau, W. K. W., Law, A. C. K., Yeung, P. K. K., & Chung, S. K. (2019). Endothelin type B receptor promotes cofilin rod formation and dendritic loss in neurons by inducing oxidative stress and cofilin activation. Journal of Biological Chemistry, 294(33), 12495-12506 Sánchez-Vidaña, D. I., Po, K. K. T., Fung, T. K. H., Chow, J. K. W., Lau, W. K. W., So, P. K., … Tsang, H. W. H. (2019). Lavender essential oil ameliorates depression-like behavior and increases neurogenesis and dendritic complexity in rats. Neuroscience Letters, 701, 180-192 Lau, W. K. W., Leung, M. K., & Lau, B. W. M. (2019). Resting-state abnormalities in Autism Spectrum Disorders: A meta-analysis. Scientific Reports, 9(1), 3892 Leung, P. P. Y., Lau, W. K. W., & Chung, C. L. P. (2019). Development and validation of perceived self-transformation scale for the Satir model.. Contemporary Family Therapy, 41(1), 56-67 Lau, W. K., Leung, P. P. Y., & Chung, C. L. P. (2018). Effects of the Satir Model on mental health: A randomized controlled trial. Research on Social Work Practice, -, 1-11 Shao, R., Lau, W. K., Leung, M. K., & Lee, T. M. C. (2018). Subgenual anterior cingulate-insula resting-state connectivity as a neural correlate to trait and state stress resilience. Brain and Cognition, 124, 73-81 Leung, M. K., Lau, W. K., Chan, C. C., Wong, S. S., Fung, A. L., & Lee, T. M. (2018). Meditation-induced neuroplastic changes in amygdala activity during negative affective processing. Social Neuroscience, 13(3), 277-288 Lau, W. K., Leung, M. K., Wing, Y. K., & Lee, T. M. (2018). Potential mechanisms of mindfulness in improving sleep and distress. Mindfulness, 9(2), 547-555 Cheng, L., Lau, W. K., Fung, T. K., Lau, B. W., Chau, B. K., So, K. F.,...Lee, T. M. (2017). PM2.5 exposure suppress dendritic maturation in subgranular zone in aged rats. Neurotoxicity Research, 32(1), 50-57 Lau, W. K., Leung, M. K., Law, A. C., & Lee, T. M. (2017). Moderating effects of cortisol on neural-cognitive association in cognitively normal elderly subjects. Frontiers in Aging Neuroscience, 9, 163 Lau, W. K., Cui, L. Y., Chan, S. C., Ip, M. S., & Mak, J. C. (2016). The presence of serotonin in cigarette smoke – A possible mechanistic link to 5-HT-induced airway inflammation. Free Radical Research, 50(5), 495-502 Lau, W. K., Leung, M. K., Lee, T. M., & Law, A. C. (2016). Resting-state abnormalities in amnestic mild cognitive impairment: a meta-analysis. Translational Psychiatry, 6(4), e790 Lau, W. K. W., Leung, M. K., Chan, C. C. H., Wong, S. S. Y., & Lee, T. M. C. (2015). Can the neural-cortisol association be moderated by experience-induced changes in awareness?. Scientific Reports, 5(1), 1-10 Lau WK, Li X, Yeung DS, Chan KH, Ip MS, Mak JC (2012). The involvement of serotonin metabolism in cigarette smoke-induced oxidative stress in rat lung in vivo. Free Radical Research, 46, 1413-1419 Lau, W. K., Chan, S. C., Law, A. C., Ip, M. S., & Mak, J. C. (2012). The role of MAPK and Nrf2 pathways in ketanserin-elicited attenuation of cigarette smoke-induced IL-8 production in human bronchial epithelial cells. Toxicological Sciences, 125, 569-577 Lau, W. K., Chan-Yeung, M. M., Yip, B. H., Cheung, A. H., Ip, M. S., Mak, J. C., & the COPD Study Group of the Hong Kong Thoracic Society (2012). The role of circulating Serotonin in the development of Chronic Obstructive Pulmonary Disease. PLoS One, 7, e31617 Lau WK, Mak JC, Chan KH, Law AC (2011). Cigarette smoke-induced cerebral cortical interleukin-6 elevation is not mediated through oxidative stress. Neurotoxicity Research, 22, 170-176 Chao, J., Lau, W. K., Huie, M. J., Ho, Y. S., Yu, M. S., Lai, C. S.,...Chang, R. C. (2010). A pro-drug of the green tea polyphenol (-)-epigallocatechin-3-gallate (EGCG) prevents differentiated SH-SY5Y cells from toxicity induced by 6-hydroxydopamine. Neuroscience Letters, 469, 360-364 Cheung, Y. T., Lau, W. K., Yu, M. S., Lai, C. S., Yeung, S. C., So, K. F., & Chang, R. C. (2009). Effects of all-trans-retinoic acid on human SH-SY5Y neuroblastoma as in vitro model in neurotoxicity research. Neurotoxicology, 30, 127-135

Scholarly Books, Monographs and Chapters
Leung, M.K., & Lau, W.K.W. (2020). Resting-state abnormalities of posterior cingulate in autism spectrum disorder. ., In Progress in molecular biology and translational science (.-.). Cambridge, MA: Academic Press, an imprint of Elsevier. (in press)
Leung, J. W. H., Lau, W. K. W., Lau, B. W. M., & Yee, B. K. (2019). A commentary on the therapeutic potential of melatonin and its analogues in CNS conditions. In P. A. Garguilo, H. L. Mesones Arroyo (Eds.), Psychiatry and Neuroscience Update (177-186). Cham: Springer International Publishing

Journal Publications
Lau, W. K. W. (2022). The role of resilience in depression and anxiety symptoms: A three-wave cross-lagged study. Stress and Health Doi:10.1002/smi.3136.
Zhu, Z., Wang, Y., Lau, W. K. W., Wei, X., Liu, Y., Huang, R., & Zhang, R. (2022). Hyperconnectivity between the posterior cingulate and middle frontal and temporal gyrus in depression: Based on functional connectivity meta-analyses. Brain Imaging and Behavior Doi:10.1007/s11682-022-00628-7.
Lau, W. K., Ngan, L. H., Chan, R. C., Wu, W. K., Lau, B. W. (2021). Impact of COVID-19 on pornography use: evidence from big data analyses. PLoS One, ., .-.
Tai, A. P., Lau, W. K. (2021). Revisit the Effectiveness of Educational Kinesiology on Stress and Anxiety Amelioration in Kindergarteners with Special Needs using Biological Measures. Frontiers in Psychiatry, 12, .-.
Wang, C., Wang, Y., Lau, W. K. W., Wei, X., Feng, X., Zhang, C., . . . Zhang, R. (2021). Anomalous static and dynamic functional connectivity of amygdala subregions in individuals with high trait anxiety. Depression and Anxiety, 38(8), 860-873
Zhao, G., Lau, W. K., Wang, C., Yan, H., Zhang, C., Lin, K., ... & Zhang, R. (2021). A Comparative Multimodal Meta-analysis of Anisotropy and Volume Abnormalities in White Matter in People Suffering From Bipolar Disorder or Schizophrenia. Schizophrenia Bulletin, ., .-.
Lau, W. K. W., Tai, A. P. L., Chan, J. N. M., Lau, B. W. M., & Geng, X. (2021). Integrative psycho-biophysiological markers in predicting psychological resilience. Psychoneuroendocrinology, 129, .-.
Lau, W. K. W., Tai, A. P. L., & Lau, C. S. Y. (2021). An integrated training approach for ameliorating repetitive behavior in children with autism spectrum disorder: A pilot study.. Hong Kong Journal of Special Education., 22, 1-16
Peng, X., Lau, W. K. W., Wang, C., Ning, L., & Zhang, R. (2020). Impaired left amygdala resting state functional connectivity in subthreshold depression individuals. Scientific Reports, 10(1), .-.
Lau, W.K.W., Leung, M.K. & Zhang, R (2020). Hypofunctional connectivity between the posterior cingulate cortex and ventromedial prefrontal cortex in autism: evidence from coordinate-based imaging meta-analysis. Progress in neuropsychopharmacology and  biological psychiatry, in press, .-.
Tam, S. W., Feng, R., Lau, W. K. W., Law, A. C. K., Yeung, P. K. K., & Chung, S. K. (2019). Endothelin type B receptor promotes cofilin rod formation and dendritic loss in neurons by inducing oxidative stress and cofilin activation. Journal of Biological Chemistry, 294(33), 12495-12506
Sánchez-Vidaña, D. I., Po, K. K. T., Fung, T. K. H., Chow, J. K. W., Lau, W. K. W., So, P. K., … Tsang, H. W. H. (2019). Lavender essential oil ameliorates depression-like behavior and increases neurogenesis and dendritic complexity in rats. Neuroscience Letters, 701, 180-192
Lau, W. K. W., Leung, M. K., & Lau, B. W. M. (2019). Resting-state abnormalities in Autism Spectrum Disorders: A meta-analysis. Scientific Reports, 9(1), 3892
Leung, P. P. Y., Lau, W. K. W., & Chung, C. L. P. (2019). Development and validation of perceived self-transformation scale for the Satir model.. Contemporary Family Therapy, 41(1), 56-67
Lau, W. K., Leung, P. P. Y., & Chung, C. L. P. (2018). Effects of the Satir Model on mental health: A randomized controlled trial. Research on Social Work Practice, -, 1-11
Shao, R., Lau, W. K., Leung, M. K., & Lee, T. M. C. (2018). Subgenual anterior cingulate-insula resting-state connectivity as a neural correlate to trait and state stress resilience. Brain and Cognition, 124, 73-81
Leung, M. K., Lau, W. K., Chan, C. C., Wong, S. S., Fung, A. L., & Lee, T. M. (2018). Meditation-induced neuroplastic changes in amygdala activity during negative affective processing. Social Neuroscience, 13(3), 277-288
Lau, W. K., Leung, M. K., Wing, Y. K., & Lee, T. M. (2018). Potential mechanisms of mindfulness in improving sleep and distress. Mindfulness, 9(2), 547-555
Cheng, L., Lau, W. K., Fung, T. K., Lau, B. W., Chau, B. K., So, K. F.,...Lee, T. M. (2017). PM2.5 exposure suppress dendritic maturation in subgranular zone in aged rats. Neurotoxicity Research, 32(1), 50-57
Lau, W. K., Leung, M. K., Law, A. C., & Lee, T. M. (2017). Moderating effects of cortisol on neural-cognitive association in cognitively normal elderly subjects. Frontiers in Aging Neuroscience, 9, 163
Lau, W. K., Cui, L. Y., Chan, S. C., Ip, M. S., & Mak, J. C. (2016). The presence of serotonin in cigarette smoke – A possible mechanistic link to 5-HT-induced airway inflammation. Free Radical Research, 50(5), 495-502
Lau, W. K., Leung, M. K., Lee, T. M., & Law, A. C. (2016). Resting-state abnormalities in amnestic mild cognitive impairment: a meta-analysis. Translational Psychiatry, 6(4), e790
Lau, W. K. W., Leung, M. K., Chan, C. C. H., Wong, S. S. Y., & Lee, T. M. C. (2015). Can the neural-cortisol association be moderated by experience-induced changes in awareness?. Scientific Reports, 5(1), 1-10
Lau WK, Li X, Yeung DS, Chan KH, Ip MS, Mak JC (2012). The involvement of serotonin metabolism in cigarette smoke-induced oxidative stress in rat lung in vivo. Free Radical Research, 46, 1413-1419
Lau, W. K., Chan, S. C., Law, A. C., Ip, M. S., & Mak, J. C. (2012). The role of MAPK and Nrf2 pathways in ketanserin-elicited attenuation of cigarette smoke-induced IL-8 production in human bronchial epithelial cells. Toxicological Sciences, 125, 569-577
Lau, W. K., Chan-Yeung, M. M., Yip, B. H., Cheung, A. H., Ip, M. S., Mak, J. C., & the COPD Study Group of the Hong Kong Thoracic Society (2012). The role of circulating Serotonin in the development of Chronic Obstructive Pulmonary Disease. PLoS One, 7, e31617
Lau WK, Mak JC, Chan KH, Law AC (2011). Cigarette smoke-induced cerebral cortical interleukin-6 elevation is not mediated through oxidative stress. Neurotoxicity Research, 22, 170-176
Chao, J., Lau, W. K., Huie, M. J., Ho, Y. S., Yu, M. S., Lai, C. S.,...Chang, R. C. (2010). A pro-drug of the green tea polyphenol (-)-epigallocatechin-3-gallate (EGCG) prevents differentiated SH-SY5Y cells from toxicity induced by 6-hydroxydopamine. Neuroscience Letters, 469, 360-364
Cheung, Y. T., Lau, W. K., Yu, M. S., Lai, C. S., Yeung, S. C., So, K. F., & Chang, R. C. (2009). Effects of all-trans-retinoic acid on human SH-SY5Y neuroblastoma as in vitro model in neurotoxicity research. Neurotoxicology, 30, 127-135

Project


Effectiveness of Stress Mindset Training in Cultivating Resilience in Chinese Young Adults : A Randomized Control Trial Psychological resilience (hereinafter referred to as resilience) is critical for maintaining a healthy mental condition. The Stress Mindset Theory suggested that everyone had different mindsets (either enhancing or debilitating), which influenced the interpretation of stress and selection of coping styles under adversities. Cortisol, an important physiological marker of resilience, was moderated by different types of mindsets. Stress mindsets could be moderated by watching either enhancing or debilitating videos. However, the effect of mindset training has never been tested in Chinese population, and the effect of mindset training on resilience is largely unknown. The current proposed study aims to examine the effectiveness of the intervention of stress mindsets and the association with different operationally defined resilience in Chinese young adults. Three hundred young adults will be recruited (50% SIE, 50% SID) and randomly assigned to the SIE video group or the control group. Their resilience levels, stress mindsets as well as saliva cortisol levels will be measured before and after the mindset training, as well as after one month follow-up. Findings from this study could inform the effectiveness of stress mindset intervention for educators and health caretakers in loal settings. Project Start Year: 2021, Principal Investigator(s): LAU, Kwok Wai 劉國威
Effectiveness of Music Therapy in Social Skill Intervention for Children with ASD/ID: A Randomized Controlled Trial -- Project Start Year: 2020, Principal Investigator(s): YUM, Yen Na Cherry 任演納 (LAU, Kwok Wai 劉國威 as Co-Investigator)
Integrative Biophysiological Markers for Predicting Psychological Resilience: A Longitudinal Study Impact: Development of objective measures for psychological resilience in University students Project Start Year: 2020, Principal Investigator(s): LAU, Kwok Wai 劉國威
Long Range Resting-state Abnormalities of the Posterior Cingulate in Autism Spectrum Disorder: A Meta-Analysis Long range resting-state abnormalities of the posterior cingulate in autism spectrum disorder: A meta-analysis Project Start Year: 2019, Principal Investigator(s): LAU, Kwok Wai 劉國威
Can the Cantonese Pediatric Lexical-tone Dichotic Listening Test Identify Macro- and Micro-structural Corpus Callosum Deficits in Very Young Cantonese Speakers by Structural MRI Investigation? This study adopted the structural MRI technique to cross-evaluate the sensitivity and reliability of the Cantonese Pediatric Lexical-Tone Dichotic Listening Test in very young Cantonese speakers with SLI. Project Start Year: 2019, Principal Investigator(s): LAU, Kwok Wai 劉國威
An Interdisciplinary Research Laboratory for Biomarkers Analysis in Education Studies: Laboratory for Educational Sciences (LES) The current project aims to set up a bioanalytical laboratory for processing and analyzing human biological samples, to guide applied education studies by providing objective data in determining the effectiveness of various intervention programmes or teaching strategies. Project Start Year: 2019, Principal Investigator(s): LAU, Kwok Wai 劉國威
Resting-state Abnormalities in Autistic Spectrum Disorders: A Meta-analysis This project summarized the local resting-state abnormalities in ASD compared to TD control using an activation likelihood estimation (ALE) method. Project Start Year: 2018, Principal Investigator(s): LAU, Kwok Wai 劉國威
Investigation on Integrative Biomarkers of Psychological Resilience The project adopted biophysiological measures, such as stress hormones and heart rate variability to predict psychological resilience in a group of undergraduate / postgraduate students. Project Start Year: 2018, Principal Investigator(s): LAU, Kwok Wai 劉國威

Prizes and awards


Internal Research Grant 2018/19 (Duration: 1 year) Date of receipt: 17/5/2019, Conferred by: The Education University of Hong Kong
Central Reserve Allocation Committee Fund (Duration: 3 years) Date of receipt: 22/3/2019, Conferred by: The Education University of Hong Kong
Start-up Research Grant Date of receipt: /3/2018, Conferred by: EdUHK